What games have you tried?
- Morrowind doesn't start after the launcher.
- Manhunt runs at 5 FPS. Five!
- Oddworld: Abe's Odyssey doesn't start
- Deus Ex is too slow to be playable
- Jet Set Radio doesn't start
- Half-Life Blue Shift works well
And I’m running what the community has dubbed the best way, crossover with cxpatcher.
The rule of thumb is generally that for Windows games pre-2008ish, Parallels is a better choice, since they tend to rely on weird corners of Windows compatibility and 32-bit performance in Wine is still not always great. DXVK + MoltenVK is generally the best choice for anything post-2000s, pre-DX11, and GPT/D3DM is generally the best choice for anything DX11/DX12.