"Neo: You ever have that feeling where you're not sure if you're awake or still dreaming? Choi: All the time. It's called mescaline, it's the only way to fly"

-- The Matrix https://www.youtube.com/watch?v=kdAMq5LdAvs

Isolated in 1896 and synthesized in 1919. Havelock Ellis described the use of cactus Anhalonium lewinii, or mescal button by Kiowa Indians (New Mexico) in "Mescal: A New Artificial Paradise" (1898). Aldous Huxley took mescaline for the first time on May 3, 1953 and subsequently wrote about it in Doors of Perception (1954) and Heaven and Hell (1956). Jim Morrison co-founded The Doors, named after Huxley's book, in July 1965 in Los Angeles, California. He formed the band with Ray Manzarek, whom he met at the UCLA School of Theater, Film and Television when they were both students.

Carlos Castaneda, himself a kind of enigma and his books controversial wrote his first book shortly after, "The Teachings of Don Juan: A Yaqui Way of Knowledge," published in 1968,

Oh right! Mescaline became known in the US artistic and scientific circles a bit earlier than psilocybin.