This should be a deal breaker for any serious app. Does the performance hit of safe mode negate all other advantages of MongoDB?
[1] But as Artur Bergman so eloquently points out, if your data can fit in ram, just use a native data-structure (http://youtu.be/oebqlzblfyo?t=13m35s)
We have done billions of ops with Mongo and have never lost any data.