The key is to define the term "large" in this context. Pull requests size is an artifact of a humans brain ability to process changes. Therefore its best to tailor the content of a PR based on how difficult you think it is for the stakeholders you are merging can understand the change. "large" is more a measure of complexity.

When I make changes to a codebase that very few people are experts in and is generally perceived to be difficult to understand, I make "smaller" pull requests so that the change log is followable and changes easier revert.

As with many things in software development: be pragmatic, think of others, and do the best you can.