I haven't used an ad blocker in a decade. The web is perfectly safe and usable. What do you believe makes it unsafe and unusable?
From the Wikipedia page you linked, it's clear all vectors for automatic intrusion and traditional pop-up fakery are well blocked. Even malicious spoof sites are being blocked at record speeds on the browser level.
In addition, ads are not the only (or even the primary) method of malware delivery. At best if you think an ad-blocker makes you "safe", this is a false sense of security.
If you apply common sense, there's no scenario where normal web browsing is "unsafe".
But the amount of social engineering (trying to trick users into installing malware), scams, and obvious misinfo (the "you won't believe what car Greta is driving" ads for example) is mind-blowing. Even shopping ads often turn out to be worse-than-Temu "sell the worst piece of undersized crap China can crank out, promising a money-back guarantee that turns out to be worthless" scams.
Making sure tech-inexperienced friends and relatives have an ad blocker makes a night-and-day difference in the amount of damage control and cleanup you'll have to deal with.
I understand there are people who need safety rails (or shouldn't be using computers at all), but that doesn't really negate my point.
Most ads are not malicious, and the web is perfectly usable and safe without an ad blocker, providing you use common sense.
I've personally been hit by malicious ad(s) at work. Definitely embarrassing as an engineer, especially when I wasn't looking at anything work-inappropriate (it's been ages, don't recall what I was looking for).
Google can spin this however they like, but this is blatantly anti-consumer behavior only enabled by their monopoly position. The FTC should already be investigating over this, but, alas, they seem distracted by other issues.
I've not tried Firefox in years, but this will likely be the catalyst to me switching. I assume Edge follow will follow suit (and I've no reason to see why they won't since it's chromium based).
I'm not sure why I need to be to think that the web is not "unsafe and unusable" without an adblocker.