I think the main problem for female science entrepreneurs is they're in the tiny sliver of the Venn diagram where Entrepreneurial women (a minority, but perhaps larger than the amount of male entrepreneurs) and women in science (a minority no matter how you slice it) meet. There are many self-employed women working as fashion designers, restauranteurs, Innkeepers, real-estate agents, and Yoga instructors. There are likewise millions (or at least hundreds of thousands) of women in the sciences and in engineering, but yaw, they're a minority. Finally, some of these entrepreneurial engineer women are attractive. But now you're getting into a minority among a minority among a minority, and it is unlikely any of these women would be noteworthy if compared to the richest entrepreneurs (Rockefeller, Vanderbilt), the most prominent scientists (Feynman, Newton), or the most beautiful people. For someone who is also a woman [1] to be notable in all three fields would be astronomically unlikely even if these fields were not somewhat incompatible [2]. If a woman is fairly good at all three fields, that's amazing, but it shouldn't come as a surprise that she is neither very attractive compared the most beautiful women or very talented compared to the best programmers.
[1] Notable women are presumably twice as scarce of notable people or either gender.
[2] One can only do so much with one's life, especially if one aims at being the best at something.