I don't know if I agree or disagree with your general thesis, but it has to be pointed out that the JavaScript ecosystem is even more complex than Python -- despite the fact that it doesn't have to deal with a C ABI -- and I think this is in fact largely because the language has resisted change so much that everything has just moved beyond the language itself to some form of transpilation.

The world changes. Software development changes. The best way to guarantee that your entire codebase will become an obsolete monolith that eventually needs to get replaced is to make sure that you choose an ecosystem that isn't growing and changing too.

Yes, there are COBOL and Fortran and whatever else programs still running out there. But software is not mostly a "one and done" thing, and unless you're confident you're writing something that's "one and done", then these comparisons are truly irrelevant.