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Comment by ekianjo | Hacker News Reader

It is

Edit: sorry this was intended for the parent comment.

It is but K2 absorption is complex as well. It’s not quite as straightforward as something like salt and potassium intake etc.

Additionally there’s just so much about gut health that we operate largely out of ignorance on. Even simple things like the prevalence of intestinal and other parasites in North America etc are tinged with ignorance or bad backing data

So what dosage would you recommend in terms of both and also is it always contingent on getting a blood test? Like it can't hurt to supp the minimum?

Edit: are there any a prioris you can offer as a basic jumping off point inline with your commentary?

> So what dosage would you recommend in terms of both and also is it always contingent on getting a blood test?

It is very personal, and as your body makes D3 when exposed to sunlight it also varies significantly with the seasons.

Ya but its winter so lets say its statistically insignificant? What do?

Edit: aha, thought experiment ;) just talking about this earlier

Edit: to child reply: surely it can't be that touchy or non-robust. Not asking for medical advice ;) just give me a floor to investigate

It’s really hard to say without bloodwork since unique sun and gut absorption rates plus other things that affect your gut can affect your absorption.

K Mayo Clinic says 600IU/daily. I'll take a 1000iu/with a K2 every other day maybe

600 iu is way too little. Your body can make 20 000 IU when exposed to the sun for half an hour. 600 IU is the equivalent of placebo

What do you think about hyperdosing D3 like a few times a month? Heard about that, something something lipophilic...

There's the NIH guidelines here:

https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessiona...

If possible I'd suggest working through this with a qualified physician.

(I know this is a cliche response, but it seemed worth mentioning.)

> Even simple things like the prevalence of intestinal and other parasites in North America etc are tinged with ignorance or bad backing data

Tangentially related, but there is pretty strong evidence that having some types of gut parasites is actually largely a benefit due to the way they modify our immune responses.

Like toxoplasmosis or what are the endemic species?

https://en.wikipedia.org/wiki/Helminthic_therapy

>"Additionally there's just so much about gut health that we operate largely out of ignorance on."

Looking at you, probiotics. Actually, I was really impressed at how far we've come in probiotics after attending supply side west. Lots of focus on how to target specific outcomes through supplementation of specific bacterial strains. But still, there's a lot we do not know

Do we know if supplementing with a particular bacterium has a straightforward, corresponding effect in the gut flora?

I have no idea how complicated the gut / flora dynamics are in response to such a treatment.

E.g., maybe adding bacterium A triggers a die-off of bacterium B, and thus a population explosion of bacterium C, causing reduced diarrhea, leading to growth of D, causing inactivation of E, ...

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