There probably wouldn't exist any type of inteligent animal to wonder about it, since life and the evolution of life kind of requires chemestry to be a thing.
It's clearly a much deeper question, given even Wigner wrote a paper about it. He called it a miracle.
Look, ultimately, mathematics is abstract and the physical world is material. The fact that an abstract condition is able to affect material conditions is literally a miracle that can only be explained metaphysically.