The Fermi paradox isn’t what I would point to. It makes a lot of assumptions.
The rare earth hypothesis is much more rooted in first principles. The earth has a very rare combination of factors all of which are crucial to life as we know it, and likely anything we could recognize as life due to the factors life requires for maintaining its complexity and ability to self replicate and perpetuate. These are not limited to the specific nature of carbon, water, and oxygen in the Goldilocks zones, the necessity of a magnetosphere, in a very specific galactic structure in a specific part of such a galactic structure, making the specific envelope of Sol and earth with its unique tectonic geology, etc, all of which are literally necessary to evolve life. Other forms of life are theorized (silicon based, etc) but they have almost impossible requirements to assemble into structures complex enough with enough flow of energy without so much energy they fall apart. Every theorized xenobiology other than the one we have is likely impossible for pretty fundamental reasons. This doesn’t mean we have exhausted all possibilities or that nature won’t surprise us in crazy ways beyond our imagination, it just means life is almost certainly MUCH MUCH more rare than drakes equation lets on.
https://en.m.wikipedia.org/wiki/Rare_Earth_hypothesis
Again, I’m not saying life doesn’t exist outside earth. I’m saying we don’t know and despite really hard efforts to approach extraterrestrial life from every possible angle has been fruitless so far, even to the point we have no theories of life’s origins, how to detect life, and no open avenues that have any hope of such a discovery. At the moment it’s feeling less likely we will discover life outside the earth before we can reverse time (as we have done in simple time crystals). That should be daunting to our blind faith.
To my mind this should weigh on us as a burden. As long as we believe life exists elsewhere the loss of life on earth is sad, but ultimately inconsequential. If we are the seed of life in the practically observable universe, then we are the shepherd of the most amazing thing in all of creation. We have a responsibility to tend it, and IMO, spread it as far and wide as we can such that the universe does team with life and for the rest of all time life never feels alone.