Paradoxical effects are not uncommon. My DNA is weird. I have lots of them.
One example, is opiates make me MOVE. Most people they zonk out, not me. I'm ready to move your house, one brick at a time, with my bare hands and feel like I could knock it out in about an hour.
Proton Pump inhibitors are common meds for acid reflux. About 10 years ago, I did a genetics study (I worked at the lab, and my data stayed mine) and learned that of the 7 classes of PPIs available, at that time, my body only works with 1. The others either have little/no effect or similar.