My experience with Arq has been terrible so far. The interface keeps glitching up, for a while it failed repeatedly until I gave it a unique permission in Windows services, and the backup process is far from intuitive, with multiple backups showing up as restore options, but each with different file sizes and specific files saved. Overall, just too many ambiguities for it to be reliable.

Oddly, SpiderOak has been a background go-to for years and always worked smoothly for backing up everything I select in a wholesale way, keeping a fairly clear record of what was saved, removed or moved, and adjusting immediately to any file changes or deletes I do. The SO interface is shitty and often freezes, and lacks many basic features like being able to see file sizes or scrolling through long file lists easily, but at least overall, I can quickly and easily see when backups are happening, how they're being done and what's being saved. Also, for restoring files, it's surprisingly fast despite a reputation held by many that it's slow.

Arq is the best set-and-forget option I know of for macOS.