The 1783 Laki eruption comes to my mind. Back then, a 25km long fissure with 130 vents opened. About 14km3 of lava and 1km3 of tephra was emitted. Lava fountains were estimated to have reached between 800m and 1400m.
Some 20-25% of the population died, 50% of cattle and 50% of the horse population perished.
It is argued that this eruption was the catalyst for the French Revolution, as the amount of emitted gasses caused extreme weather patterns across Europe (and the world) throughout the 1780s leading to famine, diseases and social unrest.
https://en.wikipedia.org/wiki/Laki
In contemporary times, there's the 1973 eruption of Eldfell on the island of Heimaey. It destroyed some 400 homes and led to a temporary evacuation of some 5.300 inhabitants. By 1975, some 80% of the population had returned. Moreover, today it's the foremost fishing center of Island with over 1/3rd of the total fish catch originating from its harbor.