Imagine the case where you're trying to create a storage system for a large number of virtual machine images (e.g., you're trying to build your own equivalent of AWS Machine Images). There is obviously a lot of duplication between parts of images. And not necessarily at the same offset, but also at different offsets that are n*2^k bytes apart, where 2^k represents the block/sector size.
You could consider building this storage system on top of BLAKE3's tree model. Namely you store blocks as small Merkle tree. And an image is basically a collection of blocks that has a different 'hat' on top of it. Unfortunately, BLAKE3 makes this hard, because the same block will end up having a different Merkle tree node depending on the offset at which it's stored.