I've used tmux and screen on occasion, but I can't get past the fact that they don't fit well with GUI terminals. I love having "GUI" scroll-back, which I can go through with mouse scroll-wheel, or just dragging the scroll bar up and down.
set -g mode-mouse on
setw -g mouse-select-window on
setw -g mouse-select-pane on
When you click-drag you're now triggering a tmux selection, not the native terminal-emulator highlight. This is a big problem because the emulated variant is slow and behaves nothing like the real thing.
To my understanding this is also a problem that can't be solved without further terminal emulator support. As it stands the remote application (tmux) can either receive all mouse-events or none of them.
This means you have to choose between scroll-wheel support plus broken text-selection - or no scroll-wheel support.
Sadly not for me. I'm a die-hard vim-user but I can't live without my scroll-wheel in the terminal.
I have following in my .tmux.conf:
set -g history-limit 1000
# See https://wiki.archlinux.org/index.php/Tmux#Scrolling_issues
set -g terminal-overrides 'xterm*:smcup@:rmcup@'