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Wegovy's heart benefits due to more than weight loss, Novo says

reuters.com

37 pointsJeremyNT16 comments

It seems like inhibition of autophagy is a key contributor to the cardiovascular effects of metabolic syndrome. Imitating GLP shifts the metabolism towards a fasting state. This means you get all the benefits of time restricted eating or caloric restriction while still drinking coke and eating candy all day.

> ... while still drinking coke and eating candy all day.

Shouldn't the drinking and eating largely disappear while the person is using semaglutide? Being that's the main point of it?

From experience, appetite mostly goes away, and when I do get hungry it doesn’t take much to fill me up. My wife basically eats almost nothing, but I find I still need to eat a small amount several times a day.

I do tend to eat more candy tho than I did on other diets - several times a week I will get the feelings of low blood sugar, and a few bites usually fixes that without affecting weight loss.

> From experience, appetite mostly goes away, and when I do get hungry it doesn’t take much to fill me up. My wife basically eats almost nothing, but I find I still need to eat a small amount several times a day.

So basically exactly like being in Ketosis? Which is free.

To use the keto drug. For 1 day don't consume more than 10 - 20g of carbs. Repeat that for 2 weeks. Keep repeating for 4 - 6 months. This drug is an appetite suppressant and you burn fat.

GLP-1 agonists are in an entirely different universe of appetite suppression compared to ketogenic diets.

Free and substantially more difficult than taking a shot. I think semaglutide et al are going to be troublesome at a societal level [0] but the “duh, simply diet!” attitude is just obviously detached from reality. It turns out it’s not simple at all for most people.

I lost decent weight via keto so I’m an advocate, but I don’t think you’re approaching this productively. It’s at least challenging for nearly everyone, especially at first.

[0] food producers are already figuring out how to respond to 10-30% intake reduction… my guess: pack more flavor onto less satiating and higher calorie foods.

I hear you what you are saying but I'm not advocating traditional dieting, which is just cutting calories and almost impossible in our society. Keto, on the other hand, allows you to eat a ton of foods without cutting calories and feeling hungry at all times. Eventually you lose some appetite and lose even more weight.

What about my comment, in which I said that I have successfully used and advocate for keto, makes you think I was talking about "traditional dieting?"

Keto is challenging for most people, too. I agree it's much easier than how most people attempt to do caloric restriction, but it still is nowhere close to taking a shot.

Eating out at restaurants can be challenging, mixing keto with e.g. vegetarianism can be challenging, certain social gatherings (like holidays) can be challenging, the brain fog (temporary as it is) can be challenging, etc. etc.

Again, none of this to suggest semaglutide et al. are without side effects or difficulties, but things that require willpower are definitionally hard, and keto is definitely one of those things.

Have you tried both to compare? I have and I would say my experience is contrary to everything you state. Keto weight loss was slow and temporal, ozempic makes me feel like a normal human.

Keto weight loss has been incredibly fast for me and my wife. We were both at almost 10lbs a month which was probably too much. I've been off for around 2 months and haven't gained anything back, but still staying lower carb, but higher quality. Making better choices. Still not drinking calories which is a big one.

and you are assuming that something that worked for you works for everyone, telling the world how everyone else is wrong even though you are prescribing the faddest diet of the 2000s that every overweight person has already tried

Is it possible to promote autophagy pathways without fasting or exercise? Not too much of course; excessive autophagy can cause cardiac cellular death.

Rapamycin likely does this.

I'm kinda conflicted about one blogger saying IF benefits happen only due to "calories in calories out", and another saying regular guys can trigger autophagy daily and rejuvinate themselves. Is the latter a possibility?

Reads line an ad and also stinks like damage control after what Reuters posted last month regarding GI track issues. [1]

[1] https://www.reuters.com/business/healthcare-pharmaceuticals/...

Tract*

I honestly don't know what to say about someone who can't recognize their own intestinal blockage. Perhaps ask patients to keep a BM journal and flag anomolies?

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