>Upon inhalation of ZnO nanoparticles, serious local effects in the lung were observed. Even if this may be due to the solubilized Zn ions, the effects are a direct result of the exposure to the ZnO nanoparticles. Therefore, the SCCS is of the opinion that, on the basis of available information, the use of ZnO nanoparticles in spray products cannot be considered safe.