See: Spanish invasion of the Americas. Hundreds of Spanish soldiers with superior technology and bad intentions VS. thousands of native Americans.
The Spaniards did not do it alone. This is a fact very easy to prove. It always shocks me to see people in North America complaining about Spaniards, when in North America there is less than 1% native Americans, the rest were exterminated, ethnic cleansed. In most hispanic countries, native and mixed people are over 70% of the population.