One of the first things I saw Linux do was utilize two mouses with two separate mouse pointers (serial and ps2 at the time), I was a young teenager and it blew my mind and I was installing Linux at home by the end of the month.
update: I looked it up. you had to change the game config and change permissions on the mouse device. so not that bad considering.
With two separate cursors on screen? I don't think so.