I use an ad blocker just as a blanket response to too much crap on websites and being uninterested in having advertising be in my face as much as it would be without. However, that's not to say that all advertising is irrelevant, or that I'm immune to it. When an ad gets through usually my response is something to the tune of "oh well".

The devil's advocate argument against your second to last point is that you'd actually be getting higher value from getting an ad on the eyeballs of an adblock user, because your ad is a bigger slice of the total ads they might see in a day. Do you want your ad to be 10% of the total ads somebody sees, or 0.5%?