What makes you think that Youtube will "lose"? From a technical perspective, they have been rather conservative in their efforts so far. It can get so much worse, they could bake ads directly into the video stream or automatically randomize their API.

Don't forget that Google also owns Chrome, which by its dominance over the market can be used to effectuate DRM (such as widevine, or web integrity). They also own the Chrome Web Store, and they can ban any extensions that bypass Youtube ads (they already ban extensions with the ability to download Youtube videos, strangely they allow downloaders for any other site).

Google has a lot of money, and a lot of fingers in critically important pies, to make their wishes a reality should they deem to do so.