Head of agency only gives a shit about billable hours, not sustainable revenue.
CTO gives a shit about shiny new tech objects, not how appropriate they are for the news of the client.
Manager gives a shit about over-committing and shipping gawd-awful soltions, and not the integrity and esteem of the team.
Team members give a shit about not making waves, and bad processes and lack of growth (i.e., learning new things) persist.
Designer gives a shit about the aesthetics of the design, not about how it's going to compromise the UX.
And so on.
I've left more than one job because I'm not wired to be complicit (in someone else self-destructive shit giving), and because I give a shit about clients and users, as well as being able to look at myself in the mirror.