I did something similar this year with 12x 4tb NVMe drives. I had a 12x 2tb setup is an fashstor 12 but the CPU and RAM limitations led me to traditional RAID there. For the second NAS I just went standard parts but with extreme performance, 13900K and the like. To get the necessary PCIe lanes (since not every port would bifurcate) I used 3 4 way switches from aliexpress. Choosing a motherboard with 2 x8 cpu slots made the bandwidth not a problem, the third does hang off the demo 4.0 lanes though. The boot drive hangs directly off the cpu in the x4 slot. The 13900K actually supports ECC in the workstation motherboards as well. I just expose everything via NFS and call it a day
All in all I'm happy with it. I still use spinning rust for the backup though, no sense worrying about that. At the time it was cheaper to get 12x4 TB budget NVMe and the extra parts than go for any reasonable count of SATA SSDs, not sure if that's still true or not. SATA definitely would have been easier, e.g. stuff like in the Flashstor 12x2TB build I had to submit a kernel patch because the cheap drives were duplicating their nsids.