erm, no, perhaps most people who use Python, deal with it, because they have to. And it's about significant indentation/whitespace-defined-scope, not spaces versus tabs, though that can also cause havoc for these languages.
Sure Python is popular, like k-pop, but not necessarily because it's the best, and certainly not because of significant-whitespace, which I suspect even Guido regrets (eg in interviews, he hardly seems to defend this choice).
Yes, you often format your code anyway in a way that could be used to ascertain scopes, but to me, using an actual delimiter is like double-entry book-keeping, and easier than manual formatting; You write your code with delimiters. Your IDE formats accordingly (with style rules that you can choose BTW). If it looks weird, you messed up the delimiters and it's obvious. Not to mention copy/pasting code, moving blocks around, etc; all fraught or painful with significant indentation.
Form follows function, not the other way around, IMHO.