Sure for a content-site template, blog, or something else fairly basic. This is not at all the case for things like art-directed super-custom designed sites like magazines, fashion brands, museums, etc, OR highly complex interactive SAAS web apps like the ones I work on. These have lots of unique considerations like complex animations, layered menus and controls, optimizing for change from mouse to touch interactions, handling the higher rate of people who use zoomed text on mobile devices, adapting to device safe areas in portrait and landscape, etc.
I am a designer and HTML/CSS coder so I am aware of the challenges from both directions.