According to the method by which NASA measures risk, it is indeed an "unacceptable risk". The red 4x4 "LxC" box stands for "likelihood x consequence". So they consider it a high likelihood and a severe consequence. It's red because that puts it in the unacceptable category.
If you look at the medical risk matrix it puts the likelihood between 60% - 80% and consequence at "loss time injury or illness per OSHA criteria" On a score of 1 (least risky) to 25 (most risky), a 4x4 scores 22.
Now to your point about "guaranteeing" they would still go, they are allowed to waive these risks through a formal process. It tends to make managers squeamish though, because nobody wants to be the person who's signature is attached to a known risk that eventually causes a mishap.
https://www.nasa.gov/wp-content/uploads/2015/10/s3001_guidel...