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Would prefer to see a few studies on other patient populations that take these drugs around the clock.

1. Pulmonary hypertension

2. Cialis (tadalafil) is like a longer acting viagra, and being prescribed for daily use to treat benign prostate hyperplasia.

Of course, these and the linked study would be associations. Could be the conditions themselves being treated are protective. Or other pesky confounders.

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PDE5 inhibitors like Viagra and Cialis have been demonstrated to improve endothelial and nerve function by improving blood supply, leading to local release of growth factors - in humans, some of the erectile function improvement is permanent, and moise models of diabetic neuropathy demonstrate lasting nerve function improvements.

They improve cerebrovascular bloodflow as well, iirc.

The odd thing is that PDE5 inhibitors have also been shown to be associated with increased risk of sensorineural hearing loss (both short term and long-term).

I believe that they have the potential to cause optic nerve compression, though severe side effects are extremely rare here. Not sure what their effect on the ear might be, but it wouldn't be the first time the same protein had wildly different effects in different parts of the body.

>that take these drugs around the clock.

I see what you did there.

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