That's a category error. You don't submit your manuscript to a prestige journal in order to publish it but to take advantage of their PR machinery. The services Nature provides are very good and cost-effective, but you have to meet their standards.
As research papers, the papers published in Nature/Science/etc. are rarely that useful. Because the journals target the general scientifically literate audience, the interesting details are usually hidden in supplementary material. And the supplements are often little more than giant info dumps that nobody has paid sufficient attention to.
It would be nice to live in a world where such PR services are unnecessary, but that's not the world we are living in. The academia is very competitive, and there is never enough funding and never enough good jobs.