Most people didn't engage, but some did. I was able to nip some onboarding issues in the bud, and develop some evangelists as well.
Some bigger companies automate this, but I always found it feels weird coming from a big company. I was always careful to put "founder" in my email signature, so the recipient knew it was coming from me. And I never sent the email right after they signed up, which might make it seem automated — even though it wasn't.