You either write HTML in JavaScript or write JavaScript in HTML. Personally, I would rather write everything in JavaScript/TypeScript than sprinkle syntactic sugar over HTML.
Yes, ultimately you need JS to interact with the DOM but if you look at eg Livewire the orchestration is in the server. I'd be happy to use a similar fullstack solution in JS/TS but afaik it doesn't exist. And it doesn't exist because the JS world is still hung up on full on fat reactive clients which are overkill for the immense majority of use cases.
If you mean, a fully TypeScript full stack solution then you might be correct. I wouldn't know because I tried Deno earlier this year and it wasn't great.
If you mean, a full stack solution that utilizes TS to for both the API and for the frontend then that is a much easier find. Vercel's Next.js provides this out-of-the-box and various other full stack starters and boilderplates exist.
I recently built one using PgTyped and typescript-rest.