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One difference would be that you can stop any treatment in case of adverse events. But you can’t remove CAR T cells from the body once they’re in.

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> you can’t remove CAR T cells

Well there working on blood purification in severe cases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245117/

"Four-day extracorporeal blood purification resulted in complete resolution of immune effector cell-associated neurotoxicity syndrome and greater than 95% reduction in interleukin-6 levels without side effects"

I mean yeah, its about balancing risks. I'm guessing that a ~2% chance of a cascade would mean that its not likley to be given as a first like of defence.

In a lot of cases we don't have other first line options. it may be no treatment die in 6 months, standard treatment die in 10 months, or this where 2% die in 1 month but 98% are cancer free 1 year later. All numbers above made up, but those are often what we are dealing with.

Of course where we have other cancer treatments that works well those should be a first line (at least for now - who knows how this will advance), but all too often we don't have good options.

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