You can see it in action on this WebGL fluid simulator[0] by PavelDoGreat.
Buffer is a subclass of Uint8Array.
High level languages will still want to do low level things
This is what I feel the node people get right over the ES people, the ES ideology is so abstracted and pushes everything out into small utility classes so you have to create a handful of different objects with odd combinations of methods to get one useful conversion done.
The ES people also seem to have no love of the CLI or for type types of debugging and testing done there. As a result, I almost always choose the node created abstractions over the ES specified ones.
So a list of floats? No! Let's not use floats everywhere just because JavaScript does.