A big difference is that, unlike computing, their instrument probably won't stop working because of some subtle change to physics introduced by a seemingly-unrelated change made to the universe by some other party in the musical instrument / air / molecules / atoms / quarks "stack". Theirs is a world with some assurance of stability.
Ours is a field built upon shifting sands. Knowing what the foundations are that the edifice you've constructed sits upon allows you to affect repairs when it crumbles unexpectedly.