Please give me an actual example, not a 17 years old video of a theoretical assembler that is still not a reality yet. From what I know, all of this is purely science fiction and worth nothing.
Although to be honest, there are indeed molecular assemblers already, except they are biological...
From what I read in your post, I must ask: what is your credential in this field and are you discussing this with good faith? It seems you have a very basic understanding of the mechanisms going on at the molecular level if you think enzyme is just about things randomly bumping into each other. Also, your description of kinesin mechanism is completely wrong. Kinesin doesn't move backward without ATP. It doesn't move at all without ATP. And it moves in one direction only unless its substrate was modified or external forces applied to it. Calling it random walk is ignorant at best and dishonest at worst.
>This is not what happens. If you actually watched a molecular dynamics simulation of a typical enzymatic reaction, and slowed it down just enough that you could see molecules moving around, it would take YEARS
There are so many things wrong with your claim. First, the same binding based on Brownian motion would happen regardless of a biological or synthetic nano assembler. All of them requires the substrates to reach them first before they can proceed to the next step and this depends on the kinetics of the reaction. Thermodynamic doesn't care if you are a polymerase or a tube of graphene. DeltaG is all that matters. But an enzyme can have specific interfacial and hydrophobic interactions built into its structure that promote binding and increase the distance it can "grab" another molecule.
An enzyme is a catalyst that lower the activation barrier. A regular reaction, which may take a day to proceed based on random chance a molecule gets a quantum fluctuation in its energy state to overcome the barrier, would get over it in an instant with an enzyme. It positions and moves the atoms around such that the reaction becomes much more favorable. That is the whole point of catalysts. An enzyme conformational changes are deliberate and extremely precise. I have said this multiple times but you keep ignoring them. Please look up the word if you don't know what conformational mean. These happens extremely fast, at femtosecond timescale, at the length scale of a few angstroms.
https://pubs.rsc.org/en/content/articlehtml/2018/cc/c8cc0242...
I didn't go too much into this because we in the catalysis field work with turnover events, which is the operation definition I gave you above. Going down to the elementary reactions is often too fast and difficult to work with. You literally can't do MD at the precision required to model some of the enzyme conformational changes.
And what do you mean by slow them down and weeks and months? If I slow any video down they will take longer to play. What matter is how long does it take in realtime. I gave you a Mhz speed enzyme. That is its real speed. It literally processes a million molecules per second by ripping out a single atom on each molecule. What do you mean by weeks and months? How are you alive if reactions take weeks to run in your body? In fact, please show me a Ghz synthetic assembler that can do the same to a molecule. I am ignorant of any but it has been some time since I was last involved with this type of research.
Honestly, I tried to give you some benefits of the doubt. But after typing all this out I afraid you and I are not talking on the same level here. So here is a simple ask: give me a real, proper, actually proven, example of a Ghz synthetic nanoassembler, a nanomachine that actually take a molecule and move it somewhere, the same way an enzyme works. No "theoretical videos" or baseless claims.