I ended up having one profile configuration file and a keyboard shortcut that toggled between two different symbolic links, plus a Gnome extension to display the currently selected profile in the top bar, so I would use one profile during the work hours and another one during the evening, but it was slow, difficult to export to other computers and just messy altogether.
So now I'm using Firefox containers and I'm mostly happy with them. I wish the bookmarks bar would change depending on the currently selected tab however.