Pepper X

I suspect neither would work to dull sensitivity to capsaicin since it works by binding directly to a specific receptor on the afferent sensory nerve cell. Repeated exposure to capsaicin probably helps as substance P is depleted.

The oils help carry the flavors and the mayo helps dull the spiciness. It's actually quite delightful and gives you a way to control how spicy you want it to be while still getting to experience the other flavors of the pepper.

Anyone have a ref while I paw through my memory slowly?

Edit: here it is, resiniferatoxin https://en.wikipedia.org/wiki/Resiniferatoxin

"Resiniferatoxin has a score of 16 billion Scoville heat units, making pure resiniferatoxin about 500 to 1000 times hotter than pure capsaicin.[...] This stimulation is followed by desensitization and analgesia, in part because the nerve endings die from calcium overload"

"At 16 billion Scoville units, resiniferatoxin is rather toxic and can inflict chemical burns in minute quantities. [...] For rats, LD50 through oral ingestion is 148.1 mg/kg.[13] It causes severe burning pain in sub-microgram (less than 1/1,000,000th of a gram) quantities when ingested orally. "

  The extensive curves and ridges of a Pepper X chili create more surface area for the plant placenta and locules to grow and retain capsaicin, adding to the intensity of heat experienced when a Pepper X is eaten.[2].

As for what to do with them: 12 large bell peppers, chop them up, remove the seeds, some baby carrots(~100-150 grams), 200 grams of tomato sauce, whatever spices your heart desires(just add some oregano), add 200 ml of water, sauce it all in a blender with two Carolinas for a minute, add another 200 ml of water and shove all that in a pot, leave it on the stove for 40-50 minutes at medium heat and that's it really. You could toss some other peppers to the mix(also pickles work well), you really can't go wrong here. You'll have hot sauce for a very long time. And that coming from me is saying a lot, considering this is my fridge at any given time: https://i.imgur.com/C6UERig.jpg

I happened to grow reapers this year since some of my seeds were too old to germinate for my Tabasco peppers. I made some reaper sauce with just a little vinegar and salt. It's really not that bad if you dilute it. Even if you put 3-5 drops in a bowl of soup you still get some reaper flavor with the heat. I probably won't grow them again as my preference is for a stronger flavor to burn ratio. But I can see how people with a higher tolerance love them.

Eating something that you know is going to be extremely unpleasant is closer to jackass territory than sport.

But if each time you do bungee-jumping you get so dizzy that you throw up and feel sick for 2 hours, then yeah, I would not understand either why one would keep doing that.

Edit: and even in that case, at least the bungee-jumping gives you an adrenaline rush. Does eating PepperX give you the same?

This is almost precisely how the "nerve induction box" in Dune is described. The one that is used to test Paul with the gom jabbar. Imagine if Gaius Helen Mohiam instead of saying "Stick your hand in the box" said, "Stick this pepper in your mouth, chew and swallow." In the book scenario Paul had to trust Mohiam that his hand was not actually being burned away, and also once the test ended she could end the pain at once. With the pepper he'd not have to trust her because he'd know about capsaicin, and she could not end the pain (unless we posit a capsaicin antidote).