I’ve had to talk to plenty of people with various levels of understanding of this, including smart hardware and FPGA types, a few radiation physics people as well, it’s not a well established “discipline” outside of some extremely small teams of engineers responsible for the sort of small batch hardened mil-spec chip fabrication runs that doesn’t really get a lot of public documentation, because while not classified, it’s extremely commercially sensitive since and the things the chips go in are usually classified to some level so there’s not a lot to work with other than some stuff that comes out of detector physics at CERN and a trickle of research papers that have come out over the years from NASA, some old DITC papers, the odd helpfully detailed SBIR grant, and some bits here and there in the occasional physics or semiconductor engineering research papers where someone gets into interesting theoretical modelling or analysis of flown hardware or something like that… it’s a niche within a niche within a niche … and the reason I know anything at all beyond being a space nerd for most of my life that was also a computer geek… is that I decided to create a startup doing space robotics, and it should be no surprise that modern robots worth the cost of putting them in space need a respectable amount of integrated circuits and all sorts of other electronics.
I think your making it seem more complicated than it really is beyond the niche nature of knowledge on the topic. It’s the typical aerospace trade triangle: sophistication vs size and weight vs cost. Except in “miniature” and having implications on software design and development. You can shield the hell out of small sensitive components but that’s going to take up size and add mass, you can get military spec parts that take up barely more room than the normal ones do but that’s going to cost a lot, you can go old school and use simpler circuit designs or larger components but this may save some money on components but increasing the size or weight which will increase the cost to get it into space…
https://www.gov.uk/government/news/jet-experiments-to-test-e...
The better biological analogy for the slow degradation of the integrated circuits due to radiation exposure would probably be heavy metal poisoning because the damage doesn’t typically spread or multiply like DNA damage and/or cancer does. Heavy metal poisoning “accumulates” it’s a slow buildup of something not meant to be there, which causes increasing problems with biological systems, until something is s disrupted by the heavy metal concentration giving a progression of symptoms until enough has built up and you get fatal symptoms.
Edit: Simple example/comparison
Everyone can (and we sadly have plenty of evidence for this) tolerate a fair bit of lead with an LD50 of 4500 to 5500 mg/kg or and a little bit of mercury with various mercury salts having an LD50 from 6-200 mg/kg, (LD50 is the abbreviation for "lethal dose, 50%", The LD50 for a substance is the dose required to kill half the members of a population.). Two heavy metals, two different levels of "exposure risks".
Similarly the metal & doped semiconductors of an integrated circuit have have different sensitives to different kinds of radiation damage. Metal interconnects will tolerate radiation differently than the silicon which is different again to the insulation substrate...
A Heavy ion, like a stray iron nucleus, (https://en.wikipedia.org/wiki/HZE_ion) is going to just dump a lot of energy and screw up a chunk of the atoms in the area around of whatever and wherever it hits, its like the mercury salts, you cant take a lot of hits like that, and fortunately they are statistically rare.
Higher energy protons, like cosmic ray protons, can cause proton induced transmutation which will slowly turn the atoms you want into the atoms you don't want, and can cause the silicon transistors themselves to change similar to how we can (and sometimes do) use neutrons to dope semiconductors in the first place (https://en.wikipedia.org/wiki/Doping_(semiconductor)#Neutron...)
Lower energy protons, and high energy electrons and positrons, can also lead to a slow buildup of electrical charges which can cause dielectric breakdowns and other unwanted effects, which can depending on what is involved and how it happens the cause of intermittent or permanent effects.
Three different kinds of radiation, three different exposure disks. They are each like different "poisons", and the total exposure, the total absorbed dose of each of them accumulates over time... until one or more of them cause something critical to happen and render the hardware inoperable.
But I checked and got second sources that matched close. So I rounded down from 5670mg/kg to a more easily to do mental math with 5500mg/kg.
It turns out the amount of lead required to kill you directly from lead poisoning is… quite a lot! But that’s kill you… your probably going to have some other lead poisoning related health problems well before that.
Edit: Re googling one of my references.
“LD50 for lead 4665 mg/kg of bodyweight in males and 5610 mg/kg of body weight in females.” from https://www.aatbio.com/resources/faq-frequently-asked-questi...