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Well, you wouldn't. It's largely a metaphysical stance rather than a scientific one[0], which I suspect is precisely why modern medicine is struggling to engage with it.

[0] Mostly. Part of it falls under Dennett's notion of an intentional stance, but that requires us to take self-report seriously, and so precludes a number of experimental designs.

You don’t. It’s fundamentally incompatible. But that’s fine.

People are able to acquire knowledge in ways besides randomized, controlled, double-blind trials. Nearly all knowledge is acquired in some other way. I say this as someone who writes A/B testing software for a living.

Could give them a psychoactive that's not reputed to help with depression. As long as they don't know what a trip looks like they won't know you gave them DMT when they're talking to the machine elves.

give patients a strong sedative (or after a period of sleep deprivation) and administer the drug while they're asleep?