Job Hunting Sucks. This Programmer Filled Out 250 Applications to Find Out Why
wired.com
wired.com
I've been unemployed 3 times in the last 15 years and each time I had at least one interview after around 5 applications.
I found the same thing worked when I was dating online (married 10 years). Show the person you read their profile and ask unique/interesting questions about it. 99.99% of the time I got a response.
Good lord, how many people did you message?!