Checkmate, biotics.
Why would such solutions be immune to the bacteria evolving escape?
Or does the 'final' bit means you accidentally kill us all by genetic engineering or nano bots?
The problem with bacteria is they are a moving target - it's not as if they aren't constantly under attack from all sides already.
Bacteriophage ( viruses that target bacteria ) are ubiquitous, there is bacteria on bacteria action ( in fact most current antibiotics are molecules one bacteria or fungi developed to kill another ), and organisms like us - are constantly trying to kill bacteria through multiple mechanisms.
Sure we do. We could stop giving out antibiotics like candy for every sprained ankle and cough to not cultivate resistance.
* Fitness is not a 1-D line. Every time a bacteria evolves resistance, it pays a cost for doing so (in lab experiments it's pretty easy to generate resistance by adding antibiotics, and the resistance factors disappear very quickly once the antibiotic is removed, suggesting a fitness cost). So even while they're getting harder to treat they're also getting less robust in general.
I never thought about it this way but this is really insightful. I was assuming it will be an endless war but if the cost gets prohibitively high to maintain resistance we have a real advantage