CR in humans builds strong muscle and stimulates healthy aging genes

CR = caloric restriction, in case anyone is wondering.

It says participants were only able to achieve a “12% reduction in calorie intake.” That’s a reduction of 240 calories a day on a 2,000 calorie diet.

The target for the two major monkey studies (that I know of) to date was a 30% reduction.

The results of those studies, which had conflicting results, showed that even at that degree of calorie restriction, dietary quality was likely more important than calorie restriction for health and longevity. Peter Attia summarizes this well here: https://peterattiamd.com/calorie-restriction-part-iia-monkey...

My takeaway from all of this is Michael Pollan’s mantra: “eat food, not too much, mostly plants.”

How do they control against the study being contaminated by the benefits of weight loss from calorie restriction?