My initial thoughts are: I don't have any reason to trust fastly or their motivations. I certainly don't have any desire to use them as a proxy server for all of my HTTP traffic.
I'll review the OHTTP spec carefully, which seems to have been put forward by mozilla (who I have limited faith in) and Cloudflare (whose motivations are suspect), and evaluate this in depth, but for now I just don't want to worry that a browser update is going to cause firefox to start sending my data to a third party.
If the concern is that websites know what our IP is due to HTTP requests, we already have some solutions for that, a VPN being a good one. Mozilla already offers a VPN.