This is a normal, yearly cycle in San Diego. I lived nearby to Qualcomm in the Mira Mesa area and it was well known then (5 years ago or so) to avoid working there due to these layoffs.
The notice for Qualcomm’s Santa Clara layoffs lists more than 150 engineering roles, including an engineering vice president. Hundreds more will lose their jobs in San Diego, as will smaller groups of business analysts, assistants and product managers, the notice says; eight San Diego-based vice presidents will also be laid off. — SF Gate