Filevault 2 is pretty good. It's built into the OS, so it's a lot more likely people will use it than to install another package.

Obviously you need to make sure you have a good backup scheme in place, and escrow the decryption key somewhere (ideally, printed).

There are some functionality advantages to Truecrypt (deniable volumes, etc.), but Filevault is pretty good. I'd feel equally comfortable with either one. (I'd prefer OPEL, the drive encryption on-controller, for performance reasons, but Mac OS X doesn't support that.)

Once you do that, you have a lot of other things to worry about before "which widely accepted disk crypto package should I use for FDE" becomes the biggest question.