The larger part of that is sales and marketing. They spend more on sales and marketing than research and development in USA. All that is wasted, publishing lots of manipulative ads and marketing material to get as many as possible to buy the most expensive medicines isn't a good use of our resources.
https://www.ahip.org/news/articles/new-study-in-the-midst-of...
2. The above link doesn't actually actually provide the study, or mention the methodology. However searching around[1] it looks like similar claims in the past have issues, mainly due to how expenses are categorized in financial statements. Specifically, advertising/marketing spend is often lumped together with general and administrative spend, which overstates that figure.
[1] https://skeptics.stackexchange.com/questions/16472/do-typica...
Risk
Who takes the risk of exploring a drug candidate that literally no one can predict will succeed or fail?Let's imagine the Secretary of Drug Development testifying before Congress on why so many of his drugs didn't work. His best strategy is to only pursue safe bets.