Blocking resources loaded over separate domains breaks a lot of sites today. Few popular sites keep everything under the same domain (CDN´s, commentsystems, captchas and Facebook/Google/Twitter-resources, for example). http://www.memebase.com is probably the worst "offender" I've come across. Hacker News isn't one of them, which I'm happy to see.
Although if this was implemented I could see a lot of sites moving quickly to remedy this, reducing the alerts. It'd still be a pretty hard transition-period, though.
Want to see how much would break today (and if the fix would work for the average user)? Try: https://www.requestpolicy.com