I haven’t had time to try Nix yet, but HomeBrew does have a declarative-ish workflow that I’ve been using for years:
Brew Bundle [1] lets you have a plaintext file listing all packages you want installed on your system. Add a line for stuff you want installed, delete a line for stuff you want removed, invoke it the right way and it will install/remove packages until your system matches the list. The initial list can be generated by “brew bundle dump” or something like that.
For configuration, I find that a normal dotfile repo cloned into my ~/.config (with a script that maintains symlinks to config files in e.g. ~/Library) works well enough for my use.