As soon as I observe the behavior or output of an agent or AI, the configuration of my brain changes. This is somewhat tautological as observation is connected to memory and thus brain changes.

I guess the more interesting question is whether there are lasting changes. I'm not an expert in learning, memory, or brain development. Even without much knowledge it should be clear that frequent interaction will have lasting changes. For example, ChatGPT is biased in the sense that it does not know about all the books that haven't been digitalized. Used frequently, those missing books will be reflected in my brain.

Another example could be a chess training AI. If I train with an AI, I could have blind spots in the landscape of chess skills that are deliberately (or not) excluded. So clearly, this AI would change my brain but not only in a way I intend.