Anecdotal: I used Saxenda (Liraglutide), for about 4 months, and whilst I did lose about 20lbs the side effects I had were awful - really bad bloating, almost gastroparesis, erectile dysfunction (which I'm sure was due to trying to push more when on the toilet).

Even with fibre supplements I had to take stool softeners daily, bisacodyl fortnightly, and I just had an awful time on them.

I had passive suicidal ideation before I started taking it, I'm not sure if it got worse though although I did once move to the more active side.

Still - on a positive note - I did for once know what it was like to not feel hungry and to not think about food 24/7 as someone who has suffered from binge eating thanks to dopamine chasing adhd.