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Looks like it may modulate the release of multiple neurotransmitters, so you may want to hold your horses on the placebo study.

https://www.frontiersin.org/articles/10.3389/fphar.2020.0127...

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Yes, most likely GLP1 is affecting the glutamate GABA balance. (GABA = Depression)

https://pubmed.ncbi.nlm.nih.gov/29129776/

GABA = depression is a crude oversimplification. Consider benzodiazepins, which cause an increase in GABA signalling as they are allosteric modulators. They cause a significant relieve in someone who is depressed.

Benzodiazepins do not increase GABA. They bind to the GABA receptor and open it up for GABA to enter.

If you are low in GABA this will make you feel less depressed. If you are high in GABA it will make you feel more depressed.

I don’t think English is their native language. You’re both saying the same thing.

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